Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy.
Ignatyeva N, Cheruiyot C, Saleem HN, Wali R, Plota D, Zhang W, Schön S, Brandenburg S, Yang Z, Steyer A, Urlaub H, Rasmussen T, Mogensen J, Pronto JRD, Döring Y, Radke MH, Shcherbata H, Lehnart SE, Janshoff A, Sossalla S, Ruhwedel T, Moebius W, Toischer K, Brügger B, Haucke V, Gotthardt M, Voigt N, Ebert A. Signal Transduct Target Ther. 2026 Jun 17;11(1):237. doi: 10.1038/s41392-026-02731-3.

Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure. 
Zimmermann WH, Ensminger S, Kutschka I, Paitazoglou C, Seidler T, Brandenburg S, Anker SD, Bader N, Bergau L, Bremmer F, Diogo PG, Eitel I, Fujita B, Gerecke B, Hasenfuß G, Hellenkamp K, Hermann-Lingen C, Jebran AF, Jurczyk D, Knaus R, Legler T, Lotz J, Placzek M, Pühler T, Riggert J, Sadlonova M, Saraei R, Ströbel P, Tiburcy M, Ullrich C, Voigt JU, Walker F, Wollnik B, Yigit G, Friede T; BioVAT-HF Investigators. N Engl J Med. 2026 May 28;394(20):1991-2001. doi: 10.1056/NEJMoa2513525.

Left atrial appendage occluder thrombosis caused embolic strokes – a case report
Riedemann GC, Maier I, Brandenburg S. Eur Heart J Case Rep. 2026 Mar 12. doi: 10.1093/ehjcr/ytag173

Dysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction.
Wegener JB, Zühlke Y, Fleischhacker C, Marks J, Foo B, Bader N, Riedemann GC, Wedemeyer J, Vu KC, Vergel Leon AM, Paulke NJ, Kohl T, Urlaub H, Schmidt C, Hasenfuß G, Moser T, Rog-Zielinska EA, Lenz C, Lehnart SE, Brandenburg S. Sci Rep. 2026 Mar 26;16(1):10488. doi: 10.1038/s41598-026-42800-9. 

Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation.
Pronto JRD, Mason FE, Rog-Zielinska EA, Fakuade FE, Bülow D, Tóth M, Machwart K, Brandes P, Wiedmann F, Kohlhaas M, Nickel A, Wolf M, Mustroph J, Vu KC, Brandenburg S, Do TQ, Siedler PJ, Ritzenhoff K, Xue Z, Zhou X, Kestel S, Dschun O, Kyshynska O, Kensah G, Rebbeck RT, El-Essawi A, Jebran AF, Danner BC, Baraki H, Schredelseker J, Bogeski I, Brundel BJJM, Lehnart SE, Bening C, Kutschka I, Bremmer F, Kallenberger SM, Rizzoli SO, Knollmann BC, Neef S, Streckfuss-Bömeke K, Schmidt C, Maack C, Voigt N. Circ Res. 2025 Nov 7;137(11):1333-1352. doi: 10.1161/CIRCRESAHA.124.325658. Epub 2025 Oct 15. 

Versatile Microfluidics Platform for Enhanced Multitarget Super-Resolution Microscopy.
Basak S, Vu KC, Mougios N, Oleksiievets N, Pollack YG, Brandenburg S, Opazo F, Lehnart SE, Enderlein J, Tsukanov R. ACS Nano. 2026 Jan 13;20(1):1590-1597. doi: 10.1021/acsnano.5c18697. Epub 2026 Jan 1.

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy.
Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart SE, Brandenburg S. Circ Res. 2024 Jul 16. doi: 10.1161/CIRCRESAHA.124.324588. Online ahead of print. 

Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction.
Lahiri SK, Lu J, Aguilar-Sanchez Y, Li H, Moreira LM, Hulsurkar MM, Mendoza A, Turkieltaub Paredes MR, Navarro-Garcia JA, Munivez E, Horist B, Moore OM, Weninger G, Brandenburg S, Lenz C, Lehnart SE, Sayeed R, Krasopoulos G, Srivastava V, Zhang L, Karch JM, Reilly S, Wehrens XHT. J Mol Cell Cardiol. 2024 Jul 2;194:85-95. doi: 10.1016/j.yjmcc.2024.06.011. Online ahead of print.

Sarcomere, troponin, and myosin X-ray diffraction signals can be resolved in single cardiomyocytes.
Bruns H, Czajka TS, Sztucki M, Brandenburg S, Salditt T.
Biophys J. 2024 Jul 2:S0006-3495(24)00439-9. doi: 10.1016/j.bpj.2024.06.029. Online ahead of print.

Structural insights into the regulation of RyR1 by S100A1.
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR.Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2400497121. doi: 10.1073/pnas.2400497121. Epub 2024 Jun 25. 

Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation.
Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack C, Linke WA, Heijman J, Lehnart SE, Kensah G, Ebert A, Mason FE, Voigt N. Circulation. 2024 Jun 24. doi: 10.1161/CIRCULATIONAHA.123.066577. Online ahead of print.

3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes.
Pochechueva TV, Schwenzer N, Kohl T, Brandenburg S, Kaltenecker G, Wollnik B, Lehnart SE.
Int J Mol Sci. 2024 Mar 10;25(6):3183. doi: 10.3390/ijms25063183. 

An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes.
Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A. Circ Res. 2023 Jul 7;133(2):e19-e46. doi: 10.1161/CIRCRESAHA.122.321157. 

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart.
Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Bockmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann T, Belousov VV, Katschinski DM. Nat Commun. 2023 Apr 14;14(1):2123. doi: 10.1038/s41467-023-37744-x. 

Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis.
Brandenburg S*, Drews L, Schönberger HL, Jacob CF, Paulke NJ, Beuthner BE, Topci R, Kohl T, Neuenroth L, Kutschka I, Urlaub H, Kück F, Leha A, Friede T, Seidler T, Jacobshagen C, Toischer K, Puls M, Hasenfuß G, Lenz C, Lehnart SE*. * corresponding authors J Mol Cell Cardiol. 2022 Dec;173:1-15. doi: 10.1016/j.yjmcc.2022.08.363. 

Calpain Cleavage of Junctophilin-2 generates a Spectrum of Calcium-dependent Cleavage Products and DNA-rich NT₁-Fragment Domains in Cardiomyocytes.
Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE.
Sci Rep. 2022 June 20;12:10387. doi: 10.1038/s41598-022-14320-9. 

A junctional cAMP compartment regulates rapid Ca²⁺ signalling in atrial myocytes.
Brandenburg S, Pawlowitz J, Steckmeister V, Subramanian H, Uhlenkamp D, Scardigli M, Mushtaq M, Amlaz SI, Kohl T, Wegener JW, Arvanitis D, Sanoudou D, Sacconi L, HasenfussG, Voigt N, Nikolaev VO, Lehnart SE. J Mol Cell Cardiol. 2022 Apr;165:141-157. doi: 10.1016/j.yjmcc.2022.01.003. 

cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias.
Berisha F, Gotz K, Wegener JW, Brandenburg S, Subramanian H, Molina CE, Rueffer A, Petersen J, Bernhardt A, Girdauskas E, Jungen C, Pape U, Kraft AE, Warnke S, Lindner D, Westermann D, Blankenberg S, Meyer C, Hasenfuss G, Lehnart SE and Nikolaev VO. Circ Res. 2021 Jun 25;129(1):81-94. doi: 10.1161/CIRCRESAHA.120.318234. Epub 2021 Apr 27. 

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes.
Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JR, Sutanto H, Pacheu Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuβ G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener JW, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE. Circ Res. 2021 Mar 19;128(6):e102-e120. doi: 10.1161/CIRCRESAHA.119.316547. Epub 2021 Jan 25. 

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
Campbell HM, Quick AP, Abu-Taha I, Chiang DY, Kramm CF, Word TA, Brandenburg S, Hulsurkar M, Alsina KM, Liu HB, Martin B, Uhlenkamp D, Moore OM, Lahiri SK, Corradini E, Kamler M, Heck AJR, Lehnart SE, Dobrev D, Wehrens XHT. Circulation. 2020 Sep 22;142(12):1159-1172. doi: 10.1161/CIRCULATIONAHA.120.045791. Epub 2020 Jul 20. 

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.
Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. Circulation. 2019 Aug 20;140(8):681-693. doi: 10.1161/CIRCULATIONAHA.119.039642. Epub 2019 Jun 12. 

Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.
Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Wehrens XH, Kohl P, Rog-Zielinska EA, Lehnart SE. JCI Insight. 2019 Jun 20;4(12):e127116. doi: 10.1172/jci.insight.127116. 

Axial Tubule Junctions Activate Atrial Ca²⁺ Release Across Species.
Brandenburg S, Pawlowitz J, Fakuade FE, Kownatzki-Danger D, Kohl T, Mitronova GY, Scardigli M, Neef J, Schmidt C, Wiedmann F, Pavone FS, Sacconi L, Kutschka I, Sossalla S, Moser T, Voigt N, Lehnart SE. Front Physiol. 2018 Oct 8;9:1227. doi: 10.3389/fphys.2018.01227. eCollection 2018. 

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE. J Clin Invest. 2016 Oct 3;126(10):3999-4015. doi: 10.1172/JCI88241. Epub 2016 Sep 19. 

The molecular and functional identities of atrial cardiomyocytes in health and disease.
Brandenburg S, Arakel EC, Schwappach B, Lehnart SE. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1882-93. doi: 10.1016/j.bbamcr.2015.11.025. Epub 2015 Nov 24. 

Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles.
Wagner E*, Brandenburg S*, Kohl T, Lehnart SE. J Vis Exp. 2014 Oct 15;(92):e51823. doi: 10.3791/51823. * shared authorship

Tuning the electrical properties of the heart by differential trafficking of K_ATP ion channel complexes.
Arakel EC*, Brandenburg S*, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B. 
J Cell Sci. 2014 May 1;127(Pt 9):2106-19. doi: 10.1242/jcs.141440. Epub 2014 Feb 25. * shared authorship